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Nutrition: Antidoxidants

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Cardiovascular Parameters in a Swine Model of Normobaric Hypoxia Treated With 5-Hydroxymethyl-2-Furfural (5-HMF)
Conclusion: 5-HMF treatment decreased P50, improved SaO2, and mitigated increases in PAP in this swine model of NH. Introduction The reduction of barometric pressure at altitude is associated with reduced partial pressure of ambient Oxygen (PO2). With lower ambient PO2, it can be anticipated that alveolar (PAO2), arterial O2 (PaO2) and blood O2 content (CaO2) will decrease accordingly, resulting in a widely recognized decrease in maximal O2 consumption (VO2) (Dill and Adams, 1972; Lucas et al., 2011). In humans, with acute exposure to altitude, maximal VO2 decrements are measurable at elevations even as low as 580 ...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research

TRAF2/ASK1/JNK Signaling Pathway Is Involved in the Lung Apoptosis of Swine Induced by Cadmium Exposure
Biol Trace Elem Res. 2021 Aug 8. doi: 10.1007/s12011-021-02860-6. Online ahead of print.ABSTRACTCadmium (Cd), a toxic heavy metal, exists widely in the environment, which can enter organisms through a variety of ways and cause damage to various organs and tissues. However, the mechanism of lung toxicity in swine after Cd exposure is still unclear. To explore the molecular mechanism of swine lung damage caused by Cd exposure, we established the model of Cd exposure, and Cd chloride (20 mg/kg CdCl2) was added to the diet of swine for continuous exposure for 40 days. TUNEL staining showed that the apoptosis of swine lung incr...
Source: Biological Trace Element Research - August 8, 2021 Category: Biology Authors: Jinxi Zhang Yue Zhang Xue Qi Yuan Cui Xiaoming Chen Hongjin Lin Source Type: research

Cadmium exposure induces mitochondrial pathway apoptosis in swine myocardium through xenobiotic receptors-mediated CYP450s activation
In this study, the cardiotoxicity of Cd(II) was investigated by establishing a Cd(II)-exposed swine model (CdCl2, 20 mg Cd/Kg diet). Terminal-deoxynucleotidyl transferase mediated nick end labeling (TUNEL) assay and transmission electron microscope were used to observe the apoptosis. Antioxidant capacity was evaluated by free radicals contents and antioxidant enzymes activities. RT-PCR and western blot were used to measure the expression of XRs, CYP450s and apoptosis-related genes. Our results revealed that Cd(II) exposure activated the XRs and increased the CYP450s expression, contributing to the production of reactive ox...
Source: Journal of Inorganic Biochemistry - February 13, 2021 Category: Biochemistry Authors: Xia Zhao Xiaojing Li Shengchen Wang Zijiang Yang Honggui Liu Shiwen Xu Source Type: research

Reduced nitric oxide bioavailability impairs myocardial oxygen balance during exercise in swine with multiple risk factors
In conclusion, five months of combined exposure to DM + HFD + CKD produces coronary endothelial dysfunction due to impaired NO bioavailability, resulting in impaired myocardial perfusion at rest and during exercise.
Source: Basic Research in Cardiology - August 26, 2021 Category: Cardiology Source Type: research

Redox Potential Correlates with Changes in Metabolite Concentrations Attributable to Pathways Active in Oxidative Stress Response in Swine Traumatic Shock
Conclusions: Real-time RP measures demonstrate significant relationships with metabolites attributable to metabolic pathways involved in systemic responses to oxidative stress, as well as those involved in these processes. These data support RP measures as a feasible, biologically relevant marker of oxidative stress. As a direct measure of redox state, RP may be a useful biomarker and clinical tool in guiding diagnosis and therapy in states of increased oxidative stress and may offer value as a marker for organ injury in these states as well.
Source: Shock - June 1, 2022 Category: Emergency Medicine Tags: Basic Science Aspects (Animal Subjects) Source Type: research

Biological and phytochemical potential of < em > Baccharis trimera < /em > (Less.) DC leaf extract on swine clinical isolates
This study investigated the phenolic compounds, antioxidant and antimicrobial activity, and phytochemical potential of B. trimera leaf extract obtained by decoction on ATCC standard bacterial strains and 23 swine clinical isolates. Water was used as an extraction solvent based on the principles of green chemistry and at a low cost. The decoction process resulted in an extract rich in phenolic compounds and a high capacity for scavenging DPPH and ABTS radicals. Phytochemical analysis of aqueous extracts was performed using HPLC-DAD, and high concentrations of chlorogenic, ferulic, caffeic, and cinnamic phenolic acids were f...
Source: Natural Product Research - June 9, 2023 Category: Biochemistry Authors: Micheli Negri Brusamarello Antonio Pedro Brusamarello M ário Antônio Alves da Cunha Cleverson Busso Source Type: research

Experimental Hemorrhagic Shock Protocol in Swine Models: The Effects of 21-Aminosteroid on the Small Intestine
Conclusions Despite few initial findings of this study suggesting that administration of lazaroid U-74389G may have some potential in attenuation of the effects of hemorrhagic shock in the small intestine of swine models, no differences remained after correction for multiple comparisons was made. Therefore, further research is required to investigate this result thoroughly.
Source: Current Therapeutic Research - March 10, 2018 Category: Drugs & Pharmacology Source Type: research

Bioremediation of zinc and manganese in swine wastewater by living microalgae: Performance, mechanism, and algal biomass utilization
Bioresour Technol. 2023 Jun 21:129382. doi: 10.1016/j.biortech.2023.129382. Online ahead of print.ABSTRACTThe remediation effects of living Chlorella sp. HL on zinc and manganese in swine wastewater was investigated, and the responses of algal cells and the mechanism were explored. In the wastewater with Zn(II) concentration of 1.85 mg/L and Mn(II) of 1 or 6 mg/L, the highest removal of Zn(II) by Chlorella reached 86.72% and 97.16%, respectively, and the Mn(II) removal were 42.74% and 30.33%, respectively. The antioxidant system of cells was activated by a significant increase in superoxide dismutase and catalase enzyme ac...
Source: Bioresource Technology - June 23, 2023 Category: Biotechnology Authors: Xiao-Ya Liu Yu Hong Man Liang Qing-Yu Zhai Source Type: research